DEAD-box RNA helicase DDX3X maintains the homeostasis of the Zika virus translation-replication cycle
Tomás Hernández‐Díaz, Alonso González-Poblete, Sebastián Giraldo-Ocampo, Aarón Oyarzún-Arrau, Cecilia Rojas-Fuentes, Lucía Cortesi-Patiño, Fernando Carrasco-Gálvez, Delia López-Palma, Mónica L. Acevedo, Bárbara Rojas-Araya, Marcelo Andrés López-Lastra, Aracelly Gaete-Argel, Fernando Valiente‐Echeverría, Tommaso Cupido, Matías Zúñiga-Bustos, Ricardo Soto‐Rifo
This study shows DDX3X promotes ZIKV replication in human microglia by regulating translation-replication cycle through ATP-dependent and -independent mechanisms.
bioRxiv · Mar 30, 2026 · PreprintMicrobiology