Cyclophilin D induces necrotic core formation by promoting mitochondria-mediated macrophage apoptosis in advanced atherosclerotic lesions
Jun‐ichiro Koga, Ryuta Umezu, Tomohiro Shirouzu, Yuki Kondo, Nasanbadrakh Orkhonselenge, Hiromichi Ueno, Shunsuke Katsuki, Tetsuya Matoba, Yosuke Nishimura, Masaharu Kataoka
This study shows that CypD promotes macrophage apoptosis and necrotic core formation in atherosclerosis by affecting mitochondrial function and inflammation.
bioRxiv · Sep 5, 2023 · PreprintMolecular Biology