ALDH3A2 acts as a metabolic safeguard that regulates sphingolipid metabolism to suppress DNA damage and cell death
Tomoya Hotani, Maiko Sasano, Taro Okada, Taketoshi Kajimoto, Masakazu Shinohara, Satoshi Ninagawa, Tetsushi Iwasaki, Masayuki Yokoi, Kaoru Sugasawa, Wataru Sakai
This study identifies ALDH3A2 as a metabolic safeguard that suppresses DNA damage and cell death by regulating hexadecenal metabolism during sphingolipid degradation.
bioRxiv · Jul 31, 2026 · PreprintMolecular Biology