Deep Learning-coupled Proximity Proteomics to Deconvolve Kinase Signaling In Vivo
Kanchan Jha, Daichi Shonai, Aditya Parekh, Akiyoshi Uezu, Tomoyuki Fujiyama, Hikari Yamamoto, Pooja Parameswaran, Masashi Yanagisawa, Rohit Singh, Scott H. Soderling
The paper introduces KolossuS, a deep learning framework for kinase-substrate prediction, integrated with CRISPR-based proximity proteomics to identify kinase substrates in vivo, including novel substrates associated with sleep deprivation.
bioRxiv · Apr 27, 2025 · PreprintCell Biology