Pooja Parameswaran

This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.

The paper uses in vivo proteomics and CRISPR screening to identify STXBP1 as a protective factor against α-synuclein toxicity in dopamine neurons in Parkinson's disease models.

The paper introduces KolossuS, a deep learning framework for kinase-substrate prediction, integrated with CRISPR-based proximity proteomics to identify kinase substrates in vivo, including novel substrates associated with sleep deprivation.

This study shows that presynaptic Rac1 signaling selectively regulates spatial working memory, with distinct effects on synaptic vesicles and morphology compared to postsynaptic Rac1 inhibition.