Author

Tong Wu

Scripps Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Research Focus:phylogenetics / evolution· 1 Organism:plant (other)· 1

Frequent Co-Authors

Linda Zhixia ShiiD· 2 shared Sameer Bikram ShahiD· 2 shared Xiaohua WuiD· 2 shared Youhang LiiD· 2 shared Hailong WangiD· 1 shared Isaac Ive· 1 shared Qihang YangiD· 1 shared Qing HuiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Linda Zhixia ShiORCID

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Author profile →

3 papers

Recent·Most cited

Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells

Tong Wu, Youhang Li, Yuqin Zhao, Sameer Bikram Shah, Linda Zhixia Shi, Xiaohua Wu

This study shows that BIR is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells, leading to hyper-recombination and synthetic lethality with PIF1, RAD52, and XPF.

Cell Reports · Oct 1, 2025Peer-reviewedMolecular Biology

53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR)

Sameer Bikram Shah, Youhang Li, Shibo Li, Qing Hu, Tong Wu, Yanmeng Shi, Tran Nguyen, Isaac Ive, Linda Zhixia Shi, Hailong Wang, Xiaohua Wu

This study shows that 53BP1 deficiency increases BIR-mediated hyperrecombination, leading to genome instability and potential cancer treatment opportunities.

Nature Communications · Oct 5, 2024Peer-reviewedMolecular Biology

GGDB: A Grameneae Genome Alignment Database of Homologous Genes Hierarchically Related to Evolutionary Events

Qihang Yang, Tao Liu, Tong Wu, Tianyu Lei, Yuxian Li, Xiyin Wang

The paper constructs GGDB, a database linking duplicated genes in Gramineae genomes to evolutionary events, enabling analysis of homology and structural changes.

PLANT PHYSIOLOGY · Jul 5, 2022Peer-reviewedBioinformatics