Rapamycin Differentially Impacts Germline Stem Cell Quiescence Across Diverse Genetic Backgrounds of Drosophila Melanogaster
Sahiti Peddibhotla, Miriam Gonzaga, Tricia Zhang, Yasha Goel, Jun Sun, Benjamin R. Harrison, Daniel Promislow, Hannele Ruohola‐Baker
This study shows that rapamycin affects germline stem cell quiescence differently across genetic backgrounds in Drosophila, with mitophagy playing a key role in quiescence persistence.
bioRxiv · Dec 4, 2025 · PreprintDevelopmental Biology