Revisiting the SRX paradox for myosin and myofibrils
Kerry Y. Kao, Kalen Z. Robeson, Anthony Asencio, Tristan Wasley, Timothy S. McMillen, Joseph D. Powers, Michael A. Geeves, Michael Regnier
The paper re-examines the SRX state in myosin using mant-ATP displacement assays and finds no evidence of the SRX state in isolated myosin but detects two components in myofibrils, suggesting distinct myosin populations in thick filaments.
bioRxiv · Oct 29, 2026 · PreprintBiochemistry