Michael A. Geeves

The paper re-examines the SRX state in myosin using mant-ATP displacement assays and finds no evidence of the SRX state in isolated myosin but detects two components in myofibrils, suggesting distinct myosin populations in thick filaments.

This study shows that the E525K β-myosin mutation reduces cardiomyocyte contraction without altering crossbridge cycling, through structural and computational analysis.

This study investigates the R403Q mutation in beta-myosin heavy chain using porcine and human stem cell models, revealing altered contractile properties and mechanisms of hypercontractility and impaired relaxation.

The paper measures how mavacamten and deoxyATP affect the SRX/DRX ratio in porcine cardiac myofibrils using a fluorescence imaging approach.

This study identifies novel cobalamin-binding proteins in Bacteroides thetaiotaomicron and shows their role in extracellular vesicle-mediated nutrient acquisition.

This study uses single molecule imaging to analyze how phosphorylation affects myosin activity and cardiac reserve in porcine sarcomeres, identifying distinct kinetic states and their modulation by phosphorylation.

This study uses molecular dynamics simulations to investigate how 2-deoxy-ATP modifies the structure and dynamics of myosin in the interacting heads motif state.

The paper investigates how TORC2-dependent phosphorylation of myosin-1 in fission yeast affects calcium regulation and cell growth during mitotic and meiotic cycles.

The paper develops ultrafast glutamate sensors iGluu and iGluf to study high-frequency synaptic transmission, revealing presynaptic frequency-dependent filtering of spike trains.