AAV-mediated age- and circuit-dependent restoration of photoreceptor synaptic structure and function in α2δ4-associated retinal synaptopathy
Trong Thuan Ung, Gillian N. Huskin, Sanford L. Boye, Yuchen Wang
This study shows that AAV-mediated 2δ4 gene therapy can restore photoreceptor synaptic structure and function in a mouse model of retinal synaptopathy, but the effectiveness depends on age and circuit type.
bioRxiv · Jul 25, 2026 · PreprintNeuroscience