Sanford L. Boye

This study shows that AAV-mediated 2δ4 gene therapy can restore photoreceptor synaptic structure and function in a mouse model of retinal synaptopathy, but the effectiveness depends on age and circuit type.

This paper develops a dual-acting RNAi therapy targeting Hif1a and Hif2a to protect retinal cells in AMD models, showing superior efficacy compared to single-target therapies.

This study shows that SARM1 depletion prevents NMNAT1-dependent photoreceptor death and retinal degeneration in mice, identifying SARM1 as a therapeutic target for retinopathies.