Author

Tuan Minh Dao

University of South Florida

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Bioinformatics· 1

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

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Sebastien Ghent· 1 shared Taseef RahmaniD· 1 shared Vladimir Nikolaevich UverskyiD· 1 shared

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2026-2026 · peak 1/yr

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Sebastien Ghent

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BioinformaticsProteins Structure Function and BioinformaticsPeer-reviewedOct 12, 2026

✦ In-depth digest

AlphaFold3 and Intrinsically Disordered Proteins: Reliable Monomer Prediction, Unpredictable Multimer Performance

Tuan Minh Dao, Sebastien Ghent, Vladimir Nikolaevich Uversky, Taseef Rahman

AlphaFold3 pLDDT matches AlphaFold2 at calling disordered residues (Matthews correlation 0.693 vs 0.701); on disorder-containing complexes mean DockQ is similar, but interface features explain less variance (42% vs 58%).

5 citationstop 2%

protein structureprotein sequence

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