Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Iden-tify Covalent TLCD1 Inhibitors
Hayden A. Sharma, Michael Bielecki, Meredith A. Holm, Ty M. Thompson, Yue Yin, Jacob B. Cravatt, Timothy B. Ware, Alex Reed, Molhm Nassir, Tamara El‐Hayek Ewing, Bruno N. Melillo, J. Fernando Bazán, Phil S. Baran, Benjamin F. Cravatt
The paper uses stereoprobes to identify covalent ligands for proteins, revealing TLCD1 as a lipid acyltransferase inhibited by OTP stereoprobes.
Journal of the American Chemical Society · Apr 23, 2025Peer-reviewedBiochemistry