Investigating oncoprotein-mediated chromatin dysregulation in Drosophila melanogaster uncovers novel modifiers of the developmental impact of H3 K27M and EZHIP
Samuel D. Krabbenhoft, Tyler E Masuda, Yadwinder Kaur, Truman J. Do, Siddhant U. Jain, Peter W. Lewis, Melissa M. Harrison
The paper identifies chromatin regulators that modify developmental defects caused by PRC2 inhibition in Drosophila, revealing pathways that restore normal development despite disrupted H3K27me3.
bioRxiv · May 26, 2025 · PreprintDevelopmental Biology