Author

Truman J. Do

University of Wisconsin–MadisonORCID 0000-0002-4285-1773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Peter W. LewisiD· 2 shared Andrew Q. RashoffiD· 1 shared Audrey BaguetteiD· 1 shared Benjamin Aaron GarciaiD· 1 shared Caterina RussoiD· 1 shared Claudia L. KleinmaniD· 1 shared Joanna K. LempiäineniD· 1 shared Melissa M. HarrisoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Peter W. LewisORCID

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2 papers

Recent·Most cited

SUZ12-Nucleic Acid Interactions Constrain PRC2 Activity to Maintain Targeted Gene Silencing Essential to Diffuse Midline Glioma

Tyler J. Reich, Paul A. Clark, Audrey Baguette, Joanna K. Lempiäinen, Caterina Russo, Andrew Q. Rashoff, Truman J. Do, Benjamin Aaron Garcia, Claudia L. Kleinman, Nada Jabado, Zachary Scott Morris, Peter W. Lewis

The paper identifies SUZ12's nucleic acid-binding domain as critical for regulating PRC2 activity in H3 K27M gliomas, showing how it constrains enzymatic function and maintains targeted gene silencing.

bioRxiv · Jul 18, 2025 · PreprintMolecular Biology

Investigating oncoprotein-mediated chromatin dysregulation in Drosophila melanogaster uncovers novel modifiers of the developmental impact of H3 K27M and EZHIP

Samuel D. Krabbenhoft, Tyler E Masuda, Yadwinder Kaur, Truman J. Do, Siddhant U. Jain, Peter W. Lewis, Melissa M. Harrison

The paper identifies chromatin regulators that modify developmental defects caused by PRC2 inhibition in Drosophila, revealing pathways that restore normal development despite disrupted H3K27me3.

bioRxiv · May 26, 2025 · PreprintDevelopmental Biology