Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing
Mei Hong Liu, Benjamin M. Costa, Una Choi, Rachel C. Bandler, Emilie Lassen, Marta Grońska-Pęski, Adam Schwing, Zachary R. Murphy, Daniel Rosenkjær, Shany Picciotto, Vanessa Bianchi, Lucie K. Stengs, Melissa Edwards, Caitlin A. Loh, Tina K. Truong, , Gilad D. Evrony
This paper develops a single-molecule long-read sequencing method to detect single-strand DNA mismatches and damage, revealing their relationship to double-strand mutations and providing insights into mutation mechanisms in cancer and aging.
bioRxiv · Feb 19, 2023 · PreprintGenomics