Zachary R. Murphy

This study identifies BAG3's role in astrocytic proteostasis in Alzheimer's disease by showing its interactions with autophagy, proteasome, and retromer components, and its impact on Aβ clearance.

This paper develops Ultra-Rapid droplet digital PCR (UR-ddPCR) for rapid intraoperative tumor mutation detection and quantification, demonstrating its feasibility in 13 glioma cases.

This paper develops a single-molecule long-read sequencing method to detect single-strand DNA mismatches and damage, revealing their relationship to double-strand mutations and providing insights into mutation mechanisms in cancer and aging.