Uria Alcolombri

Native or promiscuous? Analyzing putative dimethylsulfoniopropionate lyases using a substrate proofing approach

The paper distinguishes native DMSP lyases from promiscuous ones using substrate profiling, finding that high activity and sensitivity to structural changes indicate native function, while low activity and crossreactivity suggest promiscuity.

DddY is a bacterial dimethylsulfoniopropionate lyase representing a new cupin enzyme superfamily with unknown primary function

This paper characterizes DddY, a bacterial DMSP lyase with cupin motifs, showing it requires a metal cofactor and belongs to a new Cupin-DLL superfamily with unknown primary function.