Mitochondrial genome editing: a possible interplay of atherosclerosis-associated mutation m.15059G>A with defective mitophagy
V. A. Khotina, V. A. Kalmykov, A. D. Zhuravlev, V. V. Sinyov, I. Sobenin, A. N. Orekhov, V. N. Sukhorukov
This study investigates how the mitochondrial mutation m.15059G>A affects mitophagy, immune tolerance, and lipid metabolism in atherosclerosis using CRISPR/Cas9 to correct the mutation in cell lines.
bioRxiv · Apr 21, 2023 · PreprintCell Biology