Cell BiologybioRxivPreprint
Mitochondrial genome editing: a possible interplay of atherosclerosis-associated mutation m.15059G>A with defective mitophagy
V. A. Khotina, V. A. Kalmykov, A. D. Zhuravlev…·V. N. Sukhorukov
This study investigates how the mitochondrial mutation m.15059G>A affects mitophagy, immune tolerance, and lipid metabolism in atherosclerosis using CRISPR/Cas9 to correct the mutation in cell lines.
DOI 10.1101/2023.04.21.537899