Synthesis and Biological Evaluation of New Isoxazolyl Steroids as Anti-Prostate Cancer Agents
A. S. Rudovich, M. Perina, A. V. Krech, M. Y. Novozhilova, A. M. Tumilovich, T. V. Shkel, I. P. Grabovec, M. Kvasnica, L. Mada, M. G. Zavialova, A. R. Mekhtiev, R. Jorda, V. N. Zhabinskii, V. A. Khripach
The paper synthesizes new isoxazolyl steroids and evaluates their anti-prostate cancer activity by testing their effects on androgen receptor signaling and CYP17A1 enzyme activity.
bioRxiv · Oct 28, 2022Pharmacology & Toxicology