Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS
V. A. Woods, R. R. Abzalimov, D. A. Keedy
This study uses HDX-MS to analyze the dynamics and allosteric responses of PTP1B, revealing how inhibitors affect protein conformation and dynamics beyond their binding sites.
bioRxiv · Jul 12, 2023Biophysics