The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model for ATIC deficiency and ZMP accumulation
R. C. Mazzarino, V. Baresova, M. Zikanova, N. Duval, T. G. Wilkinson, D. Patterson, G. N. Vacano
The paper characterizes the transcriptome of a CRISPR-Cas9-generated ATIC-null HeLa cell line under purine-supplemented and depleted conditions, identifying gene expression changes related to Alzheimer's disease and other biological processes.
Molecular Genetics and Metabolism Reports · Dec 1, 2020Peer-reviewedCell Biology