Author

T. G. Wilkinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Patterson· 3 shared G. N. Vacano· 3 shared N. Duval· 3 shared M. Zikanova· 2 shared R. C. Mazzarino· 2 shared V. Baresova· 2 shared A. Vanyushkina· 1 shared D. Macak· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

D. Patterson

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Author profile →

3 papers

Recent·Most cited

The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model for ATIC deficiency and ZMP accumulation

R. C. Mazzarino, V. Baresova, M. Zikanova, N. Duval, T. G. Wilkinson, D. Patterson, G. N. Vacano

The paper characterizes the transcriptome of a CRISPR-Cas9-generated ATIC-null HeLa cell line under purine-supplemented and depleted conditions, identifying gene expression changes related to Alzheimer's disease and other biological processes.

Molecular Genetics and Metabolism Reports · Dec 1, 2020Peer-reviewedCell Biology

Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity

R. C. Mazzarino, V. Baresova, M. Zikanova, N. Duval, T. G. Wilkinson, D. Patterson, G. N. Vacano

The paper analyzes transcriptome and metabolome changes in a GART-null HeLa cell line under different purine conditions, identifying altered CD36 expression and potential links to neurodegenerative diseases.

bioRxiv · Jun 23, 2020 · PreprintCell Biology

Reduced purine biosynthesis in humans after their divergence from Neandertals

V. Stepanova, K. E. Moczulska, G. N. Vacano, X.-c. Ju, S. Riesenberg, D. Macak, T. Maricic, L. Dombrowski, M. Schörnig, K. Anastassiadis, O. Baker, R. Naumann, E. E. Khrameeva, A. Vanyushkina, E. Stekolschikova, , S. Pääbo

The paper compares metabolomes across humans, chimpanzees, and macaques to identify reduced purine biosynthesis in humans, linked to an amino acid substitution in adenylosuccinate lyase.

bioRxiv · May 11, 2020Evolutionary Biology