Extracellular G-quadruplex and Z-DNA protect biofilms from DNase I and forms a DNAzyme with peroxidase activity
G. A. S. Minero, A. Moellebjerg, C. Thiesen, M. I. Johansen, N. P. Joergensen, V. Birkedal, D. Otzen, R. L. Meyer
This study identifies non-canonical DNA structures like G-quadruplex and Z-DNA in staphylococcal biofilms that protect against DNase I and confer peroxidase activity to eDNA.
bioRxiv · May 22, 2023 · PreprintMicrobiology