Contingency and chance erase necessity in the experimental evolution of ancestral proteins
V. C. Xie, J. Pu, B. P. H. Metzger, J. W. Thornton, B. Dickinson
This study shows that contingency and chance dominate over necessity in shaping protein sequence variation over long evolutionary timescales.
bioRxiv · Aug 29, 2020 · PreprintEvolutionary Biology