Author

B. P. H. Metzger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

A. Hodgins-Davis· 1 shared B. Dickinson· 1 shared B. Yang· 1 shared E. A. Walker· 1 shared F. Duveau· 1 shared J. Pu· 1 shared J. W. Thornton· 1 shared P. J. Wittkopp· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

A. Hodgins-Davis

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintAug 29, 2020

Contingency and chance erase necessity in the experimental evolution of ancestral proteins

V. C. Xie, J. Pu, B. P. H. Metzger…·B. Dickinson

This study shows that contingency and chance dominate over necessity in shaping protein sequence variation over long evolutionary timescales.

DOI 10.1101/2020.08.29.273581

protein sequenceexperimental assay

𝕏 PostBluesky

Evolutionary BiologybioRxivApr 3, 2018

Fitness effects of altering gene expression noise in Saccharomyces cerevisiae

F. Duveau, A. Hodgins-Davis, B. P. H. Metzger…·P. J. Wittkopp

The paper quantifies how altering gene expression noise in yeast affects fitness, showing it can be beneficial or deleterious depending on average expression levels.

DOI 10.7554/elife.37272

yeastDNA methylation

𝕏 PostBluesky