Unique structural features of mammalian NEIL2 DNA glycosylase prime its activity for diverse DNA substrates and environments
B. E. Eckenroth, V. Cao, A. M. Averill, J. A. Dragon, S. Doublie
This study presents the first crystal structure of NEIL2 DNA glycosylase, revealing its unique conformational dynamics and substrate preferences, along with characterization of three cancer variants.
bioRxiv · Feb 28, 2020Biochemistry