Allosteric activation of CwlD amidase activity by the GerS lipoprotein during Clostridioides difficile spore formation
C. Alves Feliciano, B. E. Eckenroth, O. R. Diaz, S. Doublie, A. Shen
This study determines the crystal structure of the CwlD:GerS complex in C. difficile, revealing that GerS stabilizes zinc binding to CwlD, essential for its amidase activity during spore formation.
bioRxiv · Jun 21, 2021Microbiology