Chromatin Acetylation Overrides Substrate Stiffness-Dependent Mechanoresponse and Lineage Specification in Human Mesenchymal Stem Cells
R. Joshi, S. Mukherjee, P. Muralidharan, T. Suryawanshi, P. Yadav, V. Dharnidharka, S. Shukla, A. Majumder
This study shows that chromatin acetylation overrides substrate stiffness effects on hMSCs phenotype and lineage specification by reprogramming mechanoresponse and fate decisions.
bioRxiv · Jan 4, 2022 · PreprintCell Biology