S. Shukla

Conformational switching of Arp5 subunit differentially regulates INO80 chromatin remodeling

This study identifies two distinct binding mechanisms of the Arp5 subunit in the INO80 chromatin remodeler, showing their differential roles in nucleosome positioning and dimer exchange.

BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.

This study identifies BET inhibitors as effective against GI transcriptome-positive CRPC by targeting HNF1A and HNF4G, improving outcomes in preclinical models.

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

This study investigates how ALG-2 binds membranes and proteins in a Ca2+-dependent manner, revealing its role in membrane repair and ERES function.

Fecal microbial transfer and complex carbohydrates mediate protection against COPD

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes

This study shows tau fibrils enter cells via endocytosis, accumulate in lysosomes, cause membrane damage, and nucleate cytosolic tau at lysosomes.

Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression

This study identifies lactate-driven histone lactylation as a mechanism enhancing c-Myc expression and promoting breast cancer progression through SRSF10-mediated alternative splicing.

Chromatin condensation delays human mesenchymal stem cells senescence by safeguarding nuclear damages during long-term in vitro expansion

DeepMPS: Development and validation of a deep learning model for whole slide image base prognostic prediction of low grade Lung adenocarcinoma patients

This paper develops and validates DeepMPS, a deep learning model that predicts prognosis for low-grade lung adenocarcinoma patients using histopathological images and clinical data, showing strong survival prediction performance.

8-HQA Adjusts the Number and Diversity of Bacteria in the Gut Microbiome of Spodoptera littoralis

The paper investigates how 8-HQA affects gut bacterial communities in Spodoptera littoralis larvae by altering metal ion concentrations, showing increased bacterial numbers and diversity when 8-HQA is absent.

PKM2-mediated epigenetic reprogramming regulates hypoxic expression of PFKFB3 to promote breast cancer progression

This study identifies PKM2's role in hypoxic breast cancer by regulating PFKFB3 expression through epigenetic reprogramming and HIF-1/HIF-2 interactions.

Data-Driven Design of Protein-Derived Peptide Multiplexes for Biomimetic Detection of Exhaled Breath VOC Profiles

The paper designs peptide-based sensors using machine learning and OBPs to detect VOCs in exhaled breath for disease monitoring.

Intrinsic disorder in CENP-ACse4 tail and its chaperone facilitates synergistic association for kinetochore stabilization

This study investigates the interaction between the disordered Cse4 N-tail and its chaperone Scm3, showing how their synergistic association facilitates kinetochore stabilization through electrostatic interactions and reduced disorder.

RNA-protein interactome at the Hepatitis E virus internal ribosome entry site

This study identifies the RNA-protein interactome of the Hepatitis E virus IRESl element and confirms its function as a bona fide internal ribosome entry site.

In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair

This study reconstitutes the Ca2+-dependent recruitment of the human ESCRT machinery to lysosomal membranes in vitro, identifying ALG-2 as a key mediator of this process.

Chromatin Acetylation Overrides Substrate Stiffness-Dependent Mechanoresponse and Lineage Specification in Human Mesenchymal Stem Cells

This study shows that chromatin acetylation overrides substrate stiffness effects on hMSCs phenotype and lineage specification by reprogramming mechanoresponse and fate decisions.

B.1.617.3 SARS CoV-2 spike E156G/Δ157-158 mutations contribute to reduced neutralization sensitivity and increased infectivity

This study identifies spike mutations in B.1.617.3 SARS-CoV-2 variants that reduce neutralization sensitivity and increase infectivity.

Particle Uptake Driven Phagocytosis in Macrophages and Neutrophils Enhances Bacterial Clearance

This study shows that non-stimulatory cargo-free particles enhance phagocytic ability in macrophages and neutrophils, leading to faster bacterial clearance.

TLR2 on CD4+ and CD8+ T cells promotes late control of Mycobacterium tuberculosis infection

This study shows that TLR2 on CD4+ and CD8+ T cells is important for late control of Mycobacterium tuberculosis infection, but not early control.

Individual Molecular Motors use Low Forces to bypass Roadblocks during Collective Cargo Transport

The paper measures forces exerted by individual kinesin motors during cargo transport, finding they exert less than a piconewton even when bypassing obstacles.

Comprehensive and Integrated Genomic Characterization of Human Immunome in Cancer

This study develops a network-based immunogenomics model to identify mutations affecting immune responses in cancer and suggests potential immunomodulatory drug candidates.

Mutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity

This paper identifies SMURF2-mediated ubiquitination of EGFR mutants as a mechanism enhancing receptor stability and TKI sensitivity.

Novel function of TRIP6, in brain ciliogenesis

This study identifies TRIP6 as a scaffold/co-transporter essential for mammalian ciliogenesis, showing its role in brain development and hydrocephalus.

Multiple Kinesins Induce Tension for Smooth Cargo Transport

The paper shows that small groups of kinesins use asymmetric tension and cooperation to move cargo efficiently in crowded cells.

A New Uranium Bioremediation Approach using Radio-tolerant Deinocoocus radiodurans Biofilm

This study evaluates the uranium removal efficiency of a recombinant Deinococcus radiodurans biofilm strain using a modified Arsenazo III dye method.