Daptomycin forms a stable complex with phosphatidylglycerol for selective uptake to bacterial membrane
P. Machhua, V. G. Unnithan, Y. Liu, Y. Jiang, L. Zhang, Z. Guo
This paper reveals that daptomycin forms a stable complex with phosphatidylglycerol and calcium for selective bacterial membrane uptake, explaining its mechanism and potential resistance strategies.
bioRxiv · Oct 1, 2023Biochemistry