Y. Jiang

End-to-end evaluation of pipelines for metagenome-assembled genomes reveals hidden performance gaps

The paper evaluates MAG pipelines using MAG-E, revealing performance gaps in assembly, binning, and quality control for the human gut microbiome.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Cell Storage Conditions Impact Single-Cell Proteomic Landscapes

This study examines how different cell storage conditions affect single-cell proteomic profiles using DIA-diaPASEF in 293T cells, finding significant changes in morphology and proteome composition.

TRPML1 gating modulation by allosteric mutations and lipids

This study identifies allosteric mutations and lipid interactions that modulate TRPML1 channel function, revealing structural insights into its regulation by lipids and potential therapeutic targets.

Mapping the Learning Curves of Deep Learning Networks

This paper introduces a method to map learning curves of deep learning networks, identifying insights like nonlinearity and domain distinctions across tasks.

Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1alpha-mediated glycolysis

This study identifies that impaired NK cell migration in HIV-infected individuals is due to TIGIT inhibiting HIF-1-mediated glycolysis through PI3K/AKT/mTORC1 or ERK pathways.

Determination of metal ion transport rate of human ZIP4 using stable zinc isotopes

This paper determines the turnover number of human ZIP4 using stable zinc isotopes and ICP-MS, finding it ranges from 0.08 to 0.2 s-1.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma

This study shows HIF2α prevents GLS1 clustering in mitochondria, protecting ccRCC cells from glutamine deprivation, and suggests targeting GLS1 clustering could enhance HIF2 therapy.

NaV1.7 targeted fluorescence imaging agents for nerve identification during intraoperative procedures

This paper develops fluorescent imaging agents targeting NaV1.7 to improve nerve visualization during surgery, demonstrating effectiveness in non-human primates.

Pro-renin Receptor Inhibited ABCA1/G1 Expression Associated with Low HDL-c and Promoted Atherosclerosis

This study shows that prorenin binding to (P)RR inhibits ABCA1/ABCG1 expression and cholesterol efflux, leading to dyslipidemia and atherosclerosis in hypertension.

Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response

This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.

Functional characterization of Lipid storage droplets 1 (LSD1) in growth and lipolysis of Hermetia illucens

This study investigates the role of LSD1 in lipid metabolism of Hermetia illucens, finding it promotes larval growth without affecting fat content or development.

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

Disease resistance of Brassica juncea to Sclerotinia sclerotiorum is established through the induction of indole glucosinolate biosynthesis

The paper identifies a resistant Brassica juncea line H83 and reveals a novel regulatory network involving indole glucosinolate biosynthesis in response to Sclerotinia sclerotiorum infection.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Plasma membrane order maps functional diversity in immune cells

The paper identifies immune cell subsets with distinct functional behaviors based on plasma membrane order using biophysical profiling and transcriptome analysis.

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity

The paper introduces the Natural Products Discovery Center, releasing 8490 sequenced Actinobacteria strains and highlighting their taxonomic and biosynthetic diversity.

How hibernation in frogs drives brain and reproductive evolution in opposing directions

This study shows that prolonged brumation in frogs is associated with reduced brain size and increased reproductive investment, highlighting opposing evolutionary pressures in resource allocation.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations

The paper identifies metabolic state vulnerabilities in cancer cell lines and discovers synthetically lethal associations between metabolism, mutations, and therapeutic targets.

Assessing the capacity of high-resolution commercial satellite imagery for grapevine downy mildew detection and surveillance in New York state

This study evaluates the effectiveness of high-resolution satellite imagery for detecting grapevine downy mildew using spectral data and vegetation indices.