First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation
G. Brubaker, S. W. Lorkowski, K. Gulshan, S. L. Hazen, V. Gogonea, J. D. Smith
This study shows that the first eight residues of apoA1 lower the barrier to helical bundle unfolding, enabling lipidation, while C-terminus deletion prevents this process.
bioRxiv · Aug 20, 2019Biochemistry