S. L. Hazen

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

Miltefosine attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice.

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation

This study shows that the first eight residues of apoA1 lower the barrier to helical bundle unfolding, enabling lipidation, while C-terminus deletion prevents this process.

The circulating lipidome is largely defined by sex descriptors in the GOLDN, GeneBank and the ADNI studies

The paper examines sex differences in the blood lipidome across three cohorts, finding that 60% of lipids differ between men and women, with distinct lipid class distributions.