The haploinsufficient tumor suppressor Tip60 negatively regulates the oncogenic Aurora B kinase
A. Bose, S. Sudevan, V. J. Rao, H. Shima, K. Igarashi, T. K. Kundu
This study shows Tip60 acetylates AurkB, reducing its stability and activity, suggesting Tip60 downregulation increases AurkB activity in cancer.
bioRxiv · Mar 27, 2019Biochemistry