Proteomic-based evaluation of nuclear transport of NLS-tagged trastuzumab-emtansine with enhanced cytotoxic potency.
V. Lacasse, S. Beaudoin, S. Jean, J. Leyton
The paper evaluates the nuclear transport of NLS-tagged trastuzumab-emtansine using proteomic methods and identifies importin 7 as a key NTR for its cytotoxic effect.
bioRxiv · Sep 26, 2019 · PreprintCell Biology