S. Jean

Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity

The paper shows that inhibiting autophagy in intestinal stem cells increases enteroendocrine cell differentiation via Stat92E activity in Drosophila.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Snazarus and its human ortholog SNX25 regulate autophagic flux by affecting VAMP8 endocytosis

The paper identifies Snazarus and SNX25 as regulators of autophagic flux by affecting VAMP8 endocytosis, with conserved roles in Drosophila and human cells.

The last battle of Anne of Brittany: solving mass grave through an interdisciplinary approach (paleopathology, anthropobiology, history, multiple isotopes and radiocarbon dating)

This study identifies individuals in two Breton mass graves using interdisciplinary methods, revealing they were soldiers from opposing armies during the 1491 siege of Rennes.

The early endosomal protein Rab21 is critical for enterocyte functions and intestinal homeostasis

This study shows Rab21 is essential for enterocyte function and intestinal homeostasis in Drosophila, with loss of Rab21 causing morphological defects, increased cell death, and inflammation.

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

This study shows baricitinib reduces lung inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques without affecting viral shedding or immune responses.

Proteomic-based evaluation of nuclear transport of NLS-tagged trastuzumab-emtansine with enhanced cytotoxic potency.

The paper evaluates the nuclear transport of NLS-tagged trastuzumab-emtansine using proteomic methods and identifies importin 7 as a key NTR for its cytotoxic effect.

Microbiome Stability with Chronic SIV Infection in AIDS-resistant Sooty Mangabeys

This study compares the gut microbiota stability in SIV-infected sooty mangabeys and rhesus macaques, finding that SMs maintain microbiota stability while RMs show community divergence.

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

This study identifies Snazarus as a regulator of lipid droplet organization in Drosophila adipocytes, showing its role in maintaining peripheral lipid droplets at plasma membrane contacts.