Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates
S. W. Yee, L. Ferrandez-Peral, P. Alentorn, C. Fontsere, M. Ceylan, M. L. Koleske, N. Handin, V. M. Artegoitia, G. Lara, H.-C. Chien, X. Zhou, J. Dainat, A. Zalevsky, A. Sali, C. M. Brand, , K. M. Giacomini
This study identifies SLC22A10 as a nonfunctional pseudogene in humans due to a missense mutation, while great ape orthologs retain functional uptake of estradiol-17β-glucuronide.
bioRxiv · Aug 8, 2023Pharmacology & Toxicology