Author

K. M. Giacomini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H.-C. Chien· 4 shared S. W. Yee· 4 shared L. Zou· 2 shared R. Irannejad· 2 shared X. Zhou· 2 shared A. Sali· 1 shared A. Stecula· 1 shared A. Zalevsky· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersPharmacology & Toxicology

H.-C. Chien

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates

S. W. Yee, L. Ferrandez-Peral, P. Alentorn, C. Fontsere, M. Ceylan, M. L. Koleske, N. Handin, V. M. Artegoitia, G. Lara, H.-C. Chien, X. Zhou, J. Dainat, A. Zalevsky, A. Sali, C. M. Brand, , K. M. Giacomini

This study identifies SLC22A10 as a nonfunctional pseudogene in humans due to a missense mutation, while great ape orthologs retain functional uptake of estradiol-17β-glucuronide.

bioRxiv · Aug 8, 2023Pharmacology & Toxicology

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

S. W. Yee, C. Macdonald, D. Mitrovic, X. Zhou, M. Koleske, J. Yang, D. B. Silva, P. R. Grimes, D. Trinidad, S. S. More, L. Kachuri, J. S. Witte, L. Delemotte, K. M. Giacomini, W. Coyote-Maestas

This study examines OCT1 mutations to understand their impact on drug response and identifies population-specific allele frequencies linked to LDL cholesterol levels.

bioRxiv · Jun 6, 2023 · PreprintBiophysics

Cardiac contraction and relaxation are regulated by beta 1 adrenergic receptor generated cAMP pools at distinct membrane locations

T.-Y. Lin, Q. N. Mai, H. Zhang, E. Wilson, H.-C. Chien, S. W. Yee, K. M. Giacomini, J. E. Olgin, R. Irannejad

The paper shows that beta 1 adrenergic receptor-generated cAMP pools at distinct membrane locations regulate cardiac contraction and relaxation through different PKA targets.

bioRxiv · Jul 13, 2022 · PreprintCell Biology

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

L. Zou, P. Spanogiannopoulos, H.-C. Chien, L. M. Pieper, W. Cai, N. Khuri, J. Pottel, B. Vora, Z. Ni, E. Tsakalozou, W. Zhang, B. K. Shoichet, K. M. Giacomini, P. J. Turnbaugh

The paper identifies food and drug additives that inhibit intestinal drug transporters and shows gut bacteria can inactivate these additives, reducing their inhibitory effect.

bioRxiv · Oct 28, 2019Pharmacology & Toxicology

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies

S. W. Yee, A. Stecula, H.-C. Chien, L. Zou, E. V. Feofanova, M. van Borselen, K. W. K. Cheung, N. A. Yousri, K. Suhre, J. M. Kinchen, E. Boerwinkle, R. Irannejad, B. Yu, K. M. Giacomini

The paper identifies SLC22A24 as a transporter for steroid conjugates and bile acids, linking genetic variants to steroid levels and disease.

bioRxiv · May 23, 2019Pharmacology & Toxicology