Using a lentiviral Tet-regulated miR-E shRNA dual color vector to evaluate gene function in human leukemic stem cells in vivo
H. Maat, J. Jaques, E. Vellenga, G. Huls, V. Schuringa, J. J. Schuringa
This study uses a lentiviral vector to inducibly knock down PCGF1 in human leukemia models, showing that timing of gene repression affects treatment efficacy and clonal drift in leukemic stem cells.
bioRxiv · Jul 8, 2019 · PreprintCancer Biology