Author

G. Huls

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:drug response / drug discovery· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

J. J. Schuringa· 6 shared I. Weinhauser· 3 shared D. A. Pereira-Martins· 2 shared D. Pereira-Martins· 2 shared E. Ammatuna· 2 shared E. Griessinger· 2 shared E. Rego· 2 shared E. Vellenga· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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6 shared papersCancer Biology

J. J. Schuringa

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

FAO-supported OxPhos leukemic stem cells are sensitive to cold.

E. Griessinger, D. Pereira-Martins, M. Nebout, C. Bosc, E. Saland, E. Boet, A. Sahal, J. Chiche, D. Debayle, L. Fleuriot, M. Pruis, V. De Mas, F. Vergez, C. Recher, G. Huls, , J.-F. Peyron

The paper identifies cold sensitivity as a vulnerability in FAO-supported OxPhos leukemic stem cells, which can be exploited for therapeutic targeting.

bioRxiv · Apr 17, 2023 · PreprintCancer Biology

Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages

D. A. Pereira-Martins, J. Hilberink, I. Weinhauser, E. Rego, G. Huls, J. J. Schuringa

The paper examines how thiostrepton affects tumor-associated macrophages, exploring its potential to shift their polarization from M2 to M1.

bioRxiv · Mar 23, 2023 · PreprintCancer Biology

Galectin-9 has non-apoptotic cytotoxic activity towards Acute Myeloid Leukemia independent of cytarabine resistance

G. Choukrani, N. Visser, N. Ustyanovska Avtenyuk, M. Olthuis, G. Marsman, E. Ammatuna, H. J. Lourens, T. Niki, G. Huls, E. Bremer, V. R. Wiersma

This study shows Galectin-9 induces non-apoptotic cytotoxicity in AML cells, including resistant ones, and enhances the effect of Azacytidine.

bioRxiv · Jan 12, 2023Cancer Biology

The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy

K. Lima, D. A. Pereira-Martins, L. B. L. de Miranda, J. L. Coelho-Silva, G. d. S. Leandro, I. Weinhauser, R. d. C. Cavaglieri, A. M. de Leal, W. F. da Silva, A. P. A. d. L. Lange, E. D. R. P. Velloso, E. Griessinger, J. R. Hilberink, G. Huls, J. J. Schuringa, , J. A. Machado-Neto

This study shows that THZ-P1-2, a PIP4K2 inhibitor, kills leukemia cells by disrupting mitochondrial homeostasis and autophagy, with minimal effects on healthy cells.

bioRxiv · Aug 20, 2022Pharmacology & Toxicology

M2-polarized macrophages control LSC fate by enhancing stemness, homing, immune evasion and metabolic reprogramming

I. Weinhauser, D. Pereira-Martins, L. Almeida, J. Hilberink, C. Ortiz, D. Silveira, L. Quek, C. Araujo, T. Bianco, A. Lucena-Araujo, N. Visser, S. Hogeling, A. Diepstra, E. Ammatuna, G. Huls, , J. J. Schuringa

The paper shows M2-polarized macrophages promote leukemia stem cell survival by enhancing stemness, homing, immune evasion, and metabolic reprogramming.

bioRxiv · May 6, 2022Cancer Biology

USP7 as part of non-canonical PRC1.1 is a druggable target in leukemia

H. Maat, J. Jaques, A. Rodriguez Lopez, S. Hogeling, M. P. de Vries, C. Gravesteijn, A. Brouwers-Vos, G. Huls, E. Vellenga, V. van den Boom, J. J. Schuringa

This study identifies USP7 as a therapeutic target in leukemia, particularly in TP53-mutated AML, by showing its role in non-canonical PRC1.1 complex stability and function.

bioRxiv · Jul 9, 2019Cancer Biology

Using a lentiviral Tet-regulated miR-E shRNA dual color vector to evaluate gene function in human leukemic stem cells in vivo

H. Maat, J. Jaques, E. Vellenga, G. Huls, V. Schuringa, J. J. Schuringa

This study uses a lentiviral vector to inducibly knock down PCGF1 in human leukemia models, showing that timing of gene repression affects treatment efficacy and clonal drift in leukemic stem cells.

bioRxiv · Jul 8, 2019 · PreprintCancer Biology