In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies
S. Fritzwanker, F. Nagel, A. Kliewer, V. Stammer, S. Schulz
This paper demonstrates that phosphatase inhibitors are essential for preserving phosphorylated GPCR states during immunohistochemistry, enabling accurate visualization of drug-induced receptor activation in native tissues.
bioRxiv · Jun 14, 2022Pharmacology & Toxicology