Author

A. Kliewer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

S. Fritzwanker· 3 shared S. Schulz· 3 shared C. Hoffmann· 2 shared F. Nagel· 2 shared J. Drube· 2 shared A. S. Anna Schuler· 1 shared B. Klebl· 1 shared C. Degenhart· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersPharmacology & Toxicology

S. Fritzwanker

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

J. Kaufmann, N. K. Blum, F. Nagel, A. S. Anna Schuler, J. Drube, C. Degenhart, J. Engel, J. E. Eickhoff, P. Dasgupta, S. Fritzwanker, M. Guastadisegni, C. Schulte, E. Miess-Tanneberg, H. M. Maric, M. Spetea, , S. Schulz

This paper develops a bead-based immunoassay to quantify GPCR phosphorylation for ligand profiling and GRK inhibitor screening, demonstrating its utility with selective inhibitors.

bioRxiv · Jul 25, 2022Pharmacology & Toxicology

In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies

S. Fritzwanker, F. Nagel, A. Kliewer, V. Stammer, S. Schulz

This paper demonstrates that phosphatase inhibitors are essential for preserving phosphorylated GPCR states during immunohistochemistry, enabling accurate visualization of drug-induced receptor activation in native tissues.

bioRxiv · Jun 14, 2022Pharmacology & Toxicology

GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

J. Drube, R. S. Haider, E. S. F. Matthees, M. Reichel, J. Zeiner, S. Fritzwanker, C. Ziegler, S. Barz, L. Klement, A. Kliewer, E. Miess, E. Kostenis, S. Schulz, C. Hoffmann

This study investigates the role of individual GRKs in GPCR regulation and β-arrestin interactions using GRK knockout cells and identifies distinct GRK-mediated mechanisms.

bioRxiv · Feb 12, 2021Cell Biology