CRISPR/Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells
D. Hany, V. Vafeiadou, D. Picard
The paper identifies PAICS as a driver of tamoxifen resistance in ER+ breast cancer by promoting estrogen-independent ER activity through cAMP-PKA and mTOR pathways, suggesting combined targeting of PAICS and ER as a therapeutic strategy.
bioRxiv · Jun 3, 2022Cancer Biology