Impairment of homeostatic structural plasticity caused by the autism and schizophrenia-associated 16p11.2 duplication
Marc P. Forrest, Nicolas H. Piguel, VA Bagchi, Leonardo Dionisio, Sehyoun Yoon, Marc Dos Santos, MS LeDoux, Peter Penzes
This study investigates the impact of the 16p11.2 duplication on neuronal structure and homeostatic plasticity in a mouse model, finding impaired synaptic upscaling and excessive GluA1 surface abundance.
bioRxiv · Mar 6, 2025 · PreprintNeuroscience