Author
Northwestern UniversityORCID 0000-0002-9280-7850Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Marc P. Forrest, Nicolas H. Piguel, VA Bagchi, Leonardo Dionisio, Sehyoun Yoon, Marc Dos Santos, MS LeDoux, Peter Penzes
This study investigates the impact of the 16p11.2 duplication on neuronal structure and homeostatic plasticity in a mouse model, finding impaired synaptic upscaling and excessive GluA1 surface abundance.
bioRxiv · Mar 6, 2025 · PreprintNeuroscience
Marc Dos Santos, Marc P. Forrest, Ewa K. Bomba-Warczak, Euan Parnell, Seby Louis Edassery, Kun Yang, Lindsay N. Hayes, Jennifer Marie Coughlin, Blair L. Eckman, Catherine Rose Lammert, María Dolores Martin‐de‐Saavedra, Maria V. Barbolina, Akira Sawa, Jeffrey N. Savas, Peter Penzes
This study identifies a soluble synaptic protein, 2{delta}-1, reduced in schizophrenia CSF, which enhances neuronal network dynamics and cognitive function when administered to a mouse model.
bioRxiv · Dec 26, 2024 · PreprintNeuroscience
Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yizhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, María Dolores Martin‐de‐Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Mark S. LeDoux, Jennifer A. Kearney, , Peter Penzes
This study identifies PRRT2 as a key hub in an epilepsy network disrupted by 16p11.2 duplication and shows its correction rescues multiple neuropsychiatric and seizure-related phenotypes in mice.
Nature Communications · Feb 17, 2023Peer-reviewedNeuroscience
Alena Kozlova, Siwei Zhang, Alex Kotlar, Brendan Jamison, Hanwen Zhang, Serena Qinyun Z. Shi, Marc P. Forrest, John McDaid, David J. Cutler, Michael P. Epstein, Michael E. Zwick, Zhiping P. Pang, Alan R. Sanders, Stephen T. Warren, Pablo V. Gejman, , Jubao Duan
The paper identifies OTUD7A loss-of-function mutations in schizophrenia-associated 15q13.3 deletions and shows they impair synapse development and function in human neurons.
The American Journal of Human Genetics · Aug 1, 2022Peer-reviewedNeuroscience
Siwei Zhang, Hanwen Zhang, Marc P. Forrest, Yifan Zhou, Vikram A. Bagchi, Alena Kozlova, Marc Dos Santos, Nicolas H. Piguel, Leonardo E. Dionisio, Alan R. Sanders, Zhiping P. Pang, Xin He, Peter Penzes, Jubao Duan
The paper identifies multiple genes in cis regulated by a chromatin accessibility variant that contribute to synaptic dysfunction in human neurons associated with schizophrenia.
bioRxiv · Dec 11, 2021 · PreprintGenetics
Dina Simkin, Timothy J. Searl, Brandon N Piyevsky, Marc P. Forrest, Luis A. Williams, Vaibhav Joshi, Hongkang Zhang, Steven J. Ryan, Michael Schwake, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Owen B. McManus, Graham T. Dempsey, J Gordon Millichap, , Evangelos Kiskinis
This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.
bioRxiv · Sep 22, 2020 · PreprintNeuroscience
Ruoqi Gao, Christopher P. Pratt, Sehyoun Yoon, María Dolores Martin‐de‐Saavedra, Marc P. Forrest, Peter Penzes
This study identifies Par3 as a binding partner of CNTNAP2, showing that Par3 localizes CNTNAP2 to endosomes and stabilizes its presence there.
European Journal of Neuroscience · Nov 15, 2019Peer-reviewedNeuroscience
Abolfazl Doostparast Torshizi, Chris Armoskus, Hanwen Zhang, Marc P. Forrest, Siwei Zhang, Tade Souaiaia, Oleg Vadimovich Evgrafov, James A. Knowles, Jubao Duan, Kai Wang
The paper deconvolves transcriptional networks in schizophrenia to identify TCF4 as a master regulator potentially dysregulated in the disease.
bioRxiv · Jun 1, 2019 · PreprintNeuroscience
María Dolores Martin‐de‐Saavedra, Marc Dos Santos, Olga Varea, Benjamin P. Spielman, Ruoqi Gao, Marc P. Forrest, Kristoffer Myczek, Natalia Khalatyan, Elizabeth Hall, Antonio Sanz-Clemente, Davide Comoletti, Stefan F. Lichtenthaler, Jeffrey N. Savas, Peter Penzes
bioRxiv · Apr 10, 2019 · PreprintNeuroscience