Evaluating the effects of CD8/CD4 on T cell function in terms of TCR-pMHC-coreceptor catch and slip bonds
Stefano Travaglino, Amir Hossein Kazemipour Ashkezari, Menglan Li, Valencia E. Watson, Peiwen Cong, Larissa Doudy, Hyun‐Kyu Choi, Cheng Zhu
This study evaluates how CD8/CD4 coreceptors affect T cell function by analyzing TCR-pMHC catch and slip bonds, finding that coreceptors enhance bond metrics and TCR sensitivity and specificity.
Frontiers in Immunology · Jun 5, 2026Peer-reviewedImmunology