3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure
Ashley L. Kiemen, Cristina Almagro-Pérez, Valentina Matos, André Forjaz, Alicia M. Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D. Cannon, Xuan Yuan, Sarah M. Shin, Jaanvi Mahesh Babu, Elizabeth D. Thompson, Toby C. Cornish, Won Jin Ho, Laura DeLong Wood, , Denis Wirtz
The paper profiles the immune microenvironment of PanINs in 3D at single-cell resolution to understand inflammation's role in cancer progression and finds immune heterogeneity and correlations with PanIN grade.
bioRxiv · Aug 3, 2024 · PreprintCancer Biology