Xuan Yuan

Modeling cellular influence delineates functionally relevant cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinoma.

The paper introduces FunCN, a method to analyze cellular neighborhoods in PDAC, revealing distinct immune interactions in primary and metastatic sites.

PIVOT: an open-source tool for multi-omic spatial data registration

PIVOT is an open-source tool for nonlinear registration of multi-omic spatial data, demonstrating improved throughput compared to existing workflows.

Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

The paper profiles the immune microenvironment of PanINs in 3D at single-cell resolution to understand inflammation's role in cancer progression and finds immune heterogeneity and correlations with PanIN grade.